Hardening the compute layer for AI workloads

AI Infrastructure Security

12 companies tracked by our intelligence team

Market Overview

AI Infrastructure Security addresses the foundational layer — securing the compute, network, and runtime environments where AI models are trained, stored, and served. This category includes confidential computing platforms, SASE providers with AI-specific capabilities, and specialized runtime security for AI workloads.

Confidential computing has emerged as a particularly significant sub-segment. Companies like Anjuna, Fortanix, and Mithril Security enable organizations to run AI inference and training inside hardware-encrypted enclaves, ensuring that even infrastructure operators cannot access the underlying data or models. This capability is critical for regulated industries, multi-party AI collaboration, and sovereign AI deployments — particularly relevant as governments worldwide establish data residency requirements for AI systems.

The SASE and network security giants have recognized AI as a first-class workload requiring specialized protection. Cato Networks' acquisition of Aim Security (September 2025) exemplifies this trend — traditional network security vendors are bolting on GenAI-specific capabilities including shadow AI detection, AI-specific DLP policies, and secure access controls for AI applications. Netskope, Zscaler, and Cloudflare have all introduced AI-specific security features in their platforms.

Looking ahead, the convergence of edge AI, sovereign cloud requirements, and the sheer scale of AI infrastructure spending ($200B+ in 2025 alone) ensures that AI Infrastructure Security will remain a high-growth category. The companies that can provide seamless security across hybrid AI environments — spanning public cloud, private infrastructure, and edge deployments — will be best positioned to capture enterprise budgets.

All 12 AI Infrastructure Security Companies

Anjuna
Universal confidential computing platform enabling hardware-enforced isolation and encryption for secure AI workloads.
📍 Palo Alto, CA Est. 2018
Cato Networks
SASE platform with integrated AI security capabilities. Acquired Aim Security (Sep 2025) for GenAI protection.
📍 Tel Aviv, Israel Est. 2015
Cloudflare
Web infrastructure and security company with AI gateway, firewall for AI, and Workers AI security capabilities.
📍 San Francisco, CA Est. 2009
Cylake
AI-native cybersecurity platform designed for organizations requiring total data sovereignty, operating entirely on-premises or within private cloud environment...
📍 Tel Aviv, Israel Est. 2025
Fortanix
Confidential computing and data security platform enabling secure AI workloads with runtime encryption and key management.
📍 Santa Clara, CA Est. 2016
Fortinet
Global cybersecurity platform with FortiAI integrating AI across firewalls, endpoints, and SASE for unified protection.
📍 Sunnyvale, CA Est. 2000
Mithril Security
Confidential AI company enabling secure AI deployment in trusted execution environments for privacy-preserving inference.
📍 Paris, France Est. 2021
Netskope
SASE and SSE platform with AI-specific DLP, shadow AI detection, and secure access for GenAI applications.
📍 Santa Clara, CA Est. 2012
Operant AI
Runtime AI security platform protecting AI applications and agents in production with real-time threat defense.
📍 San Francisco, CA Est. 2023
Sophos
Cybersecurity company with AI-driven endpoint, network, and managed detection response for enterprises.
📍 Abingdon, UK Est. 1985
Trend Micro
Global cybersecurity company with AI-powered threat defense across cloud, endpoint, network, and AI workloads.
📍 Tokyo, Japan Est. 1988
Zscaler
Cloud security platform with AI-powered data protection, zero-trust access, and GenAI security controls.
📍 San Jose, CA Est. 2007
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